Antimachus II, also known as Antimachus II Nikephoros (meaning "Bringer of Victory"), was a ruler of the Indo-Greek Kingdom, a Hellenistic kingdom that spanned parts of modern-day Afghanistan, Pakistan, and India. He ruled during the 2nd century BCE, and his reign is believed to have been around 160–155 BCE.

The Indo-Greek kings were descendants of Alexander the Great's campaigns and the subsequent spread of Greek culture across parts of Asia. Antimachus II's coins are some of the most valuable sources of information about his reign. The coins typically feature his portrait on the obverse, while the reverse often bears Greek deities or symbols, reflecting a blend of Greek and Indian influences. His epithet, "Nikephoros," was used to emphasize his military victories and success as a ruler. 

Though not much detailed information is known about his reign, Antimachus II is an important figure in the history of the Indo-Greek kingdoms, representing the continuation of Greek influence in South Asia long after Alexander the Great.