Murad III (Ottoman) (4 July 1546 – 16 January 1595) was Sultan of the Ottoman Empire from 1574 until his death in 1595. His rule saw battles with the Habsburgs and exhausting wars with the Safavids. The long-independent Morocco was at a time made a vassal of the empire but they would regain independence in 1582. His reign also saw the empire's expanding influence on the eastern coast of Africa. However, the empire would be beset by increasing corruption and inflation from the New World which led to unrest among the Janissary and commoners. Relations with Elizabethan England were cemented during his reign as both had a common enemy in the Spanish. He was a great patron in the arts where he commissioned the Siyer-i-Nebi and other illustrated manuscripts.

Born in Manisa, Şehzade Murad was the oldest son of Şehzade Selim and his powerful wife Nurbanu Sultan. He received a good education and learned Arabic and Persian language. After his ceremonial circumcision in 1557, Murad's grandfather, the Sultan Suleiman I, appointed him sancakbeyi (governor) of Akşehir in 1558. At the age of 18 he was appointed sancakbeyi of Saruhan. Suleiman died (1566) when Murad was 20, and his father became the new sultan, Selim II. Selim II broke with tradition by sending only his oldest son out of the palace to govern a province, assigning Murad to Manisa.

Selim died in 1574 and was succeeded by Murad, who began his reign by having his five younger brothers strangled. His authority was undermined by harem influences – more specifically, those of his mother and later of his favorite concubine Safiye Sultan, often to the detriment of Sokollu Mehmed Pasha's influence on the court. Under Selim II power had only been maintained by the effective leadership of the powerful Grand Vizier Sokollu Mehmed Pasha, who remained in office until his assassination in October 1579. During Murad's reign the northern borders with the Habsburg monarchy were defended by the Bosnian governor Hasan Predojević. The reign of Murad III was marked by exhausting wars on the empire's western and eastern fronts. The Ottomans also suffered defeats in battles such as the Battle of Sisak.